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Defects in CD4+ T cell LFA-1 integrin-dependent adhesion

CD47 decreases with cell age, and the decrease in expression, accompanied by a change in conformation, is thought to be a mechanism for recognition and clearance of aging RBCs. 7, 9 On cancer cells, several studies indicated that expression of CD47 is sustained or even increased, suggesting one mechanism by which tumor cells may escape clearance. 10, 11 Elevated expression levels of CD47 have cancer cells is the expression of CD47, a cell-surface protein that interacts with signal regulatory protein α on macrophages to block phagocytosis (15–17). HIF-1 stimulates CD47 expression in hyp-oxicbreastcancercells (18).However, whether chemotherapyalso affects the expression of CD47 has not been investigated.

Apr 19, 2016 CD47 expression on tumor cell membranes and subsequent binding to signal- regulatory protein alpha (SIRPα) on macrophages lead to a signal Jun 14, 2020 Dr Naval Daver speaks to ecancer in an online interview for the virtual EHA 2020 meeting. He describes the background, study design and Jun 15, 2019 At the 24th Congress of the European Hematology Association (EHA), David Sallman from the Moffitt Cancer Center, Tampa, US, discusses if CD19 · CD200 · CD27 · CD27 Ligand · CD28 · CD40 · CD40 Ligand · CD47 · CD48 · CTLA-4 · DNAM-1 · Galectin-9 · GITR · GITR Ligand · HVEM &m Kathleen Sakamoto and Irv Weissman has received a $1.37 million grant from CureSearch titled “Development of CD47 Monoclonal Antibody Therapy for Sep 15, 2003 In addition, CD41 was expressed on most hematopoietic progenitor cells derived in vitro from murine embryonic stem (ES) cells(Mitjavila-Garcia CD47 is a potent “don't eat me” signal that enables cancer cells to evade immune surveillance and killing by innate immune cells, such as macrophages. Nov 2, 2018 CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune mononuclear cells (MNCs) via positive immunomagnetic separation and are guaranteed to have a purity of ≥90% as indicated by CD34+ expressing cells. MiR-155 overexpression suppressed CD47 expression on myeloma cell surface, leading to induction of phagocytosis of myeloma cells by macrophages and av C Koskinen — cells from CD47-/- mice or SIRPα-mutant mice (mice lacking the signaling domain of SIRPα) showed a blunted expression of osteoblast-associated genes. The ubiquitously expressed cell surface glycoprotein CD47 is expressed by virtually all cells in the host, where it can function to regulate integrin-mediated Similarly, M2 macrophage-conditioned medium induced SW480 cell migration and CD47 expression. Factors released by macrophages were involved in this Cd47 gene (Cd47-/-) CD4+ T cell adhesion and transendothelial migration (TEM) in vivo and in vitro as a result of impaired expression of high-affinity forms of factor alpha-Pal/NRF-1 is a critical regulator of the human IAP/CD47 gene. Alpha-pal / Nrf-1 in Neurons: Alpha-pal / Nrf-1 Regulates Iap/cd47 Expression CD47 is involved in the increase in intracellular calcium concentration that This protein has broad tissue distribution, and is reduced in expression on Rh CD47 är en immunologisk artspecifik markör för själv och har for SIRPalpha dictates potency of inhibition but only at low expression levels.

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Cytoplasmic and membranous expression in a subset of tissues including brain, urinary bladder, prostate and fallopian tube. In summary, CD47 can function as a marker of self on both RBCs and platelets.

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Lack of CD47 expression promotes a markedly accelerated development of spontaneous AIHA in the autoimmune-prone nonobese diabetic mice and results in increased sensitivity to experimental AIHA induced by both IgG1 and IgG2a anti-RBC monoclonal autoantibodies in nonautoimmune C57BL/6 mice. 19 We have previously suggested that, since CD47 is expressed on virtually all cells in the host, but not 2020-07-16 · Also, CD47 expression was increased in disseminated tumoral cells in control DLBCL xenograft animals, as well as in peripheral blood lymphoma cells compared with lymph node tumoral cells from NHL patients (although note peripheral blood and lymph node cells were not harvested from the same patients), further supporting a role for CD47 in the dissemination of B-NHL tumor cells . NX_Q08722 - CD47 - Leukocyte surface antigen CD47 - Expression. Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. CD47 expression and distribution. We first analyzed CD47 mRNA expression using a published data set of bladder tumor specimens (n = 105) and matching normal urothelium obtained from sites distant to tumors (n = 52) (15, 16) with our previously established Web-based platform HEGEMON (Hierarchical Exploration of Gene Expression Microarrays Online) ().

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CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Summary of CD47 (IAP, MER6, OA3) expression in human tissue. Cytoplasmic and membranous expression in several tissues. CD47, an integrin-associated protein (IAP), is a universally expressed member of the immunoglobulin superfamily that plays a critical role in self-recognition.
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Utilizing an in vivo model in the present study, we investigated whether genetically engineered expression of mouse CD47 in rat insulinoma cells (INS-1E) could inhibit macrophage-mediated xenograft rejection. INS-1E cells transfected with the Methods: RRx-001 is a small molecule Myc inhibitor and down-regulates CD47 expression on tumor cells. We evaluated the programmed death-ligand 1 (PD-L1) status of circulating tumor cells (CTCs) pre and post RRx-001 treatment in a phase 2 clinical trial, called QUADRUPLE THREAT, where patients with previously treated SCLC received RRx-001 in combination with a platinum doublet. We hypothesized that increased CD47 expression on human AML LSC contributes to pathogenesis by inhibiting their phagocytosis through the interaction of CD47 with an inhibitory receptor on phagocytes. We found that CD47 was more highly expressed on AML LSC than their normal counterparts, and that increased CD47 expression predicted worse overall survival in three independent cohorts of adult May 26, 2017 Abstract.

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Function Tumor cells. Due to the ubiquitous expression of CD47, signaling differs according to cell type. Summary of CD47 (IAP, MER6, OA3) expression in human tissue. Cytoplasmic and membranous expression in several tissues. CD47 (IAP, MER6, OA3) protein expression summary. This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occu rs upon cell adhesion to extracellular matrix. 2020-12-01 · Regulation of CD47 expression Cytokines.

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. CD47 expression and distribution. We first analyzed CD47 mRNA expression using a published data set of bladder tumor specimens (n = 105) and matching normal urothelium obtained from sites distant to tumors (n = 52) (15, 16) with our previously established Web-based platform HEGEMON (Hierarchical Exploration of Gene Expression Microarrays Online) (). Concurrently masking CD47 to promote phagocytosis of cancer cells and eliciting an adaptive immune response through direct antibody-dependent cellular cytotoxicity (ADCC) may provide an effective therapeutic strategy. 9 –11 Furthermore, the magnitude of CD47 expression could be used as a prognostic marker for recurrence and metastasis in human breast cancer, 12 as well as the aggressiveness 2020-08-18 · High expression of CD47 in tissue-infiltrating NK cells and CD8+ T cells in EC patients can, therefore, affect the efficacy of anti-CD47 therapy in EC. Skip to main content Thank you for visiting The expression of CD47 in ATLL might be associated with hypoxia, HIF-1, or an aberration introduced by the tumor. However, the mechanism under which the expression of CD47 is regulated remains to be identified.