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Journal of Forensic Sciences 1995, 40 (1) , 13769J. Benzoylecgonine is the main metabolite of cocaine, formed by the liver and excreted in the urine. It is the compound tested for in most cocaine urine drug screens. Chemically, benzoylecgonine is the benzoate ester of ecgonine. It is a metabolites, such as ecgonine methyl ester ( EME) and benzoylecgonine ( BE), in urine and blood, are presented; a fatal cocaine poisoning case, which the of cocaine and its metabolites (benzoylecgonine and ecgonine methyl ester) in huma OF COCAINE AND ITS METABOLITES IN BLOOD AND URINE.
In contrast to urine, sweat primarily contains the parent drug, cocaine, and ecgonine methyl ester in much higher concentrations as compared to benzoylecgonine [81,82]. Kacinko et al. [82] performed a thorough study on subjects with a previous history of cocaine use. The latter route is particularly important since it is globally a route of detoxification that accounts for as much as 90% of the dose in humans, who excrete high urinary concentrations of benzoylecgonine (2), ecgonine methyl ester (3), and ecgonine (4).
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In contrast to urine, sweat primarily contains the parent drug, cocaine, and ecgonine methyl ester in much higher concentrations as compared to benzoylecgonine [81,82]. Kacinko et al. [82] performed a thorough study on subjects with a previous history of cocaine use. The latter route is particularly important since it is globally a route of detoxification that accounts for as much as 90% of the dose in humans, who excrete high urinary concentrations of benzoylecgonine (2), ecgonine methyl ester (3), and ecgonine (4).
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The limit of detection (LOD) was 50 ng/mL for both metabolites.
Vasiliades J. PMID: 2733392 [PubMed - indexed for MEDLINE] Publication Types: Letter; MeSH Terms. Cocaine/analogs & derivatives* Cocaine/urine; Humans; Specimen Handling/methods* Substances. Cocaine; ecgonine methyl ester
Visit Copyright Clearance Center. Abstract. The two major urinary metabolites of cocaine are benzoylecgonine (BE) and ecgonine methyl ester (EME).
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Ecgonine. Methylester. Nifedipin. Tetrahydrokortison Urine Testing for drugs of Abuse.
ecgonine methyl ester + benzoyl-CoA -> cocaine + coenzyme A PlantCyc CPD-9777 ecgonine methyl ester + NADP+ <--> methyl ecgonone + NADPH + 2 H+ PlantCyc CPD-9777 Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module
Chemically, benzoylecgonine is the benzoate ester of ecgonine. It is a primary metabolite of cocaine, and is pharmacologically inactive. Urinalysis.
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After extraction and sample cleanup by solid-phase extraction (SPE), the extracts were derivatized with 50 μL of MTBSTFA and analyzed by gas chromatography/mass spectrometry (GC/MS). The limit of detection (LOD) was 50 ng/mL for both metabolites. Ambre JJ, Ruo TI, Smith GL, Backes D, Smith CM 1982 Ecgonine methyl ester, a major metabolite of cocaine. J Anal Toxicol 6 : 26–29.
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It is most frequently used as a recreational drug. It is commonly snorted, inhaled as smoke, or dissolved and injected into a vein. Mental effects may include an intense feeling of happiness, sexual arousal, loss of contact with reality, or agitation. The Origin and Significance of Ecgonine Methyl Ester in Blood Samples. Journal of Analytical Toxicology, 1994.
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Ecgonine. Methylester. Nifedipin. Tetrahydrokortison Urine Testing for drugs of Abuse.
The major advantage of BE screening is that many commercial immunoassays are designed to detect BE. On the other hand, EME is more amenable to gas … 50592-5 Ecgonine methyl ester [Mass/volume] in Urine by Confirmatory method Active Part Description. LP28530-1 Ecgonine methyl ester Ecgonine methyl ester (EME) is a major metabolite of cocaine, a wide spread illicit drug of abuse. [PMID: 7876811] Source: Regenstrief LOINC, PMID: 7876811Fully-Specified Name Component Ecgonine methyl ester Property 80144-9 Ecgonine methyl ester [Presence] in Urine by Screen method Active Part Description. LP28530-1 Ecgonine methyl ester Ecgonine methyl ester (EME) is a major metabolite of cocaine, a wide spread illicit drug of abuse.